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Updated: May 29, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
Published on: June 22, 2012
Novel therapies targeting the endothelium in sickle cell disease
1Department of Hematology-Oncology, Children's Hospital & Research Center Oakland, Oakland, California 94609, USA. choppe@mail.cho.org
Abstract:
The recognition of sickle cell disease as a chronic vasculopathy characterized by endothelial injury has led to new insights into complex biological processes and offers the potential for novel pharmacological treatments. Endothelial injury has been related to impaired nitric oxide (NO) homeostasis, inflammation, oxidative stress and coagulation activation. Therapeutic agents, especially those targeting multiple pathways of endothelial injury, including inflammation, thrombosis, oxidative stress and NO dysregulation are rational candidates for further exploration in sickle cell disease. This review will discuss novel drugs, specifically targeted at the endothelium, that are currently under investigation in sickle cell disease.
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