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Related Experiment Video

Updated: May 29, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Deep brain stimulation induces rapidly reversible transcript changes in Parkinson's leucocytes.

Lilach Soreq1, Hagai Bergman, Yael Goll

  • 1Department of Medical Neurobiology (Physiology), IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Journal of Cellular and Molecular Medicine
|September 14, 2011
PubMed
Summary

Subthalamic deep brain stimulation (DBS) in Parkinson's disease (PD) patients reversibly altered gene expression in leukocytes. These changes correlated with symptom improvement, suggesting potential biomarkers for treatment efficacy.

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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Published on: March 8, 2015

Area of Science:

  • Neuroscience
  • Genomics
  • Immunology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
  • Subthalamic deep brain stimulation (DBS) is a therapeutic intervention for PD motor symptoms.
  • Leukocyte gene expression changes in PD patients are not fully understood.

Purpose of the Study:

  • To investigate the reversible effects of subthalamic DBS on leukocyte gene expression in PD patients.
  • To identify molecular signatures associated with DBS efficacy and PD.
  • To explore potential biomarkers for PD diagnosis and treatment response.

Main Methods:

  • Exon microarrays were used to compare leukocyte transcripts in 12 PD patients before and after DBS, and during ON- and OFF-stimulus states.
  • Statistical analyses identified differentially expressed genes and molecular functions.
  • Correlation analyses examined the relationship between gene expression changes and neurological DBS efficacy.

Main Results:

  • DBS induced reversible changes in 12 molecular functions and 3 biological processes.
  • Six inflammation and immune-related functions showed reversibility, correlating with DBS efficacy.
  • A 29-transcript signature distinguished pre-surgery/OFF states from post-surgery/ON states and identified PD patients.

Conclusions:

  • Subthalamic DBS dynamically modulates leukocyte gene expression in PD patients.
  • Gene expression changes reflect DBS efficacy and may serve as biomarkers for PD.
  • This transcriptomic approach holds promise for identifying therapeutic targets and assessing treatment effectiveness.