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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with

Annemieke Schuurhof1, Riny Janssen, Hanneke de Groot

  • 1Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Postbak 12 GBO, P.O.BOX 1, 3720 BA Bilthoven, The Netherlands.

Respiratory Research
|September 14, 2011
PubMed

Insights

High interleukin-10 (IL-10) levels during respiratory syncytial virus (RSV) infection predict post-bronchiolitis wheeze in infants. This finding highlights IL-10

Area of Science:

  • Pediatric respiratory infections
  • Immunology of viral diseases
  • Airway hyperresponsiveness

Background:

  • Respiratory syncytial virus (RSV) is a leading cause of infant bronchiolitis.
  • Post-bronchiolitis wheeze (PBW) affects 50% of children after RSV infection.
  • Interleukin-10 (IL-10) is implicated in RSV pathogenesis and airway hyperresponsiveness.

Purpose of the Study:

  • To investigate the in vivo role of IL-10 in RSV pathogenesis.
  • To determine the association between IL-10 levels and recurrent wheeze post-RSV bronchiolitis.
  • To examine the IL10 promoter single-nucleotide polymorphism (SNP) rs1800872 in relation to IL-10 levels and PBW.

Main Methods:

  • Study cohort: 235 infants hospitalized with RSV bronchiolitis.
  • Measurements: IL-10 levels in nasopharyngeal aspirates (NPAs) and IL10 SNP rs1800872 genotype.
  • Follow-up: Physician-diagnosed PBW assessment in 185 children (79% follow-up rate).

Main Results:

  • Infants who developed PBW had significantly higher local IL-10 levels during RSV infection (958 pg/ml) compared to those without PBW (692 pg/ml, p = 0.02).
  • The IL10 promoter SNP rs1800872 was not associated with IL-10 concentrations in NPAs.
  • Local IL-10 levels during acute RSV infection are a predictor of subsequent physician-diagnosed PBW.

Conclusions:

  • Elevated local IL-10 levels during initial RSV infection are linked to physician-diagnosed PBW.
  • This study reinforces the critical role of the IL-10 immune response in the development of PBW after RSV bronchiolitis.
  • Further research into IL-10's role may identify therapeutic targets for preventing post-RSV wheezing.
Abstract

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