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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Stroke: Introduction and Types01:29

Stroke: Introduction and Types

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Related Experiment Video

Updated: May 29, 2026

A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice
04:46

A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice

Published on: May 5, 2023

Calorie restriction and stroke.

Silvia Manzanero1, Mathias Gelderblom, Tim Magnus

  • 1School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia. t.arumugam@uq.edu.au.

Experimental & Translational Stroke Medicine
|September 14, 2011
PubMed
Summary
This summary is machine-generated.

Dietary energy restriction, including calorie reduction and intermittent fasting, may protect the brain from stroke. These dietary strategies activate protective mechanisms, reducing brain injury after ischemic events.

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Last Updated: May 29, 2026

A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice
04:46

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Published on: May 5, 2023

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Area of Science:

  • Neuroscience
  • Metabolic research
  • Gerontology

Background:

  • Stroke is a leading cause of death and disability in older adults, characterized by brain cell death due to blood vessel issues.
  • Stroke injury involves complex processes like oxidative stress, inflammation, and cell death pathways.
  • Dietary energy restriction (DER), such as calorie reduction (CR) and intermittent fasting (IF), is known to extend lifespan and mitigate age-related diseases in animal models.

Purpose of the Study:

  • To explore the protective mechanisms of dietary energy restriction against stroke-induced brain injury.
  • To investigate how CR and IF may safeguard neurons from degeneration and ischemic damage.
  • To discuss the molecular pathways activated by DER that confer neuroprotection.

Main Methods:

  • Review of experimental evidence from animal models of stroke.
  • Analysis of studies investigating the effects of calorie reduction (CR) and intermittent fasting (IF) on neuronal survival.
  • Examination of molecular mechanisms, including gene and protein expression changes.

Main Results:

  • Evidence suggests CR and IF protect neurons against degeneration in animal models.
  • DER may protect against ischemic stroke brain injury by upregulating neuroprotective factors.
  • Upregulated factors include neurotrophic factors (BDNF, bFGF), protein chaperones (Hsp70, GRP78), antioxidant enzymes (SOD, HO-1), SIRT1, uncoupling proteins, and anti-inflammatory cytokines.

Conclusions:

  • Dietary energy restriction shows promise in protecting against ischemic stroke brain injury.
  • The protective effects are likely mediated by the induction of various neurotrophic, chaperone, antioxidant, and anti-inflammatory molecules.
  • Further research into DER as a potential therapeutic or preventative strategy for stroke is warranted.