Related Experiment Video
Updated: May 29, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Delayed graft function and cotrimoxazole
1Nephrology, IIS-Fundacion Jimenez Diaz and Autonoma University of de Madrid, Madrid, Spain.
Abstract:
Acute interstitial nephritis is an infrequent cause of early allograft dysfunction. Prophylactic trimethoprim sulfamethoxazole (cotrimoxazole) is frequently prescribed early in the course of kidney transplantation. Herein we have reported a case of delayed graft function associated with eosinophilia in which the renal biopsy showed interstitial mononuclear infiltrates with abundant eosinophils. An initial methylprednisolone course failed to lower the serum creatinine, but renal function and eosinophilia persistently improved following cotrimoxazole withdrawal and a second course of steroids. Cotrimoxazole acute interstitial nephritis is an infrequent but treatable cause of kidney allograft dysfunction, which should be included in the differential diagnosis of delayed renal allograft function.
Related Concept Videos
Kidney Transplant II: Surgical Procedure
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Cryptococcal Meningitis
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
