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Updated: May 29, 2026
A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
Laryngeal allotransplantation by stages in beagles: an initial study
1Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Medical College Qingdao University, Shanghai, China.
Objective:
To establish a model of cynolaryngeal transplantation.
Methods:
Ten beagles, matched for weight (8-10 kg) were divided into five groups for allotransplantation. The vascular circulation was managed with an end-to-end or end-to-lateral anastomosis of allograft bilateral common carotid arteries to recipient bilateral common carotid arteries, and bilateral external jugular veins. The recurrent laryngeal nerve was anastomosed end-to-end. Then, a vascularized allograft was embeded in the cervical subcutaneous tissue of the recipient, and cyclosporine administered every day.
Results:
The allografts in groups 3, 4, and 5 survived up to 1 month. Groups 1 and 2 showed necrosis and cervical infection.
Conclusions:
Beagles accepted laryngeal allotransplantation by stages (laryngeal allograft fore-embed model). Allograft survival was secluded by glandular organ secretion. Immunosuppression must be continuously administered.
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