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Related Concept Videos

Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Bacteriophages of the Human Virome01:23

Bacteriophages of the Human Virome

Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
Viruses of Archaea01:29

Viruses of Archaea

Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

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Related Experiment Video

Updated: May 29, 2026

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
11:23

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

Published on: December 22, 2014

Metavir: a web server dedicated to virome analysis.

Simon Roux1, Michaël Faubladier, Antoine Mahul

  • 1Laboratoire Microorganismes: Génome et Environnement, Clermont Université, Université Blaise Pascal, BP 10448, F-63000 Clermont-Ferrand, France. simon.roux@univ-bpclermont.fr

Bioinformatics (Oxford, England)
|September 14, 2011
PubMed
Summary

Metavir is a web server for analyzing viral metagenomes (viromes). It offers unique tools for exploring viral diversity, estimating gene richness, and comparing viromes, enabling comprehensive analysis.

More Related Videos

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Related Experiment Videos

Last Updated: May 29, 2026

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
11:23

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

Published on: December 22, 2014

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Area of Science:

  • Bioinformatics
  • Virology
  • Computational Biology

Background:

  • Viral metagenomics, or viromics, presents unique analytical challenges.
  • Existing metagenome analysis tools may not fully address the specifics of viral sequences.
  • A dedicated platform is needed for comprehensive virome analysis.

Purpose of the Study:

  • To introduce Metavir, a novel web server for viral metagenome analysis.
  • To provide advanced tools for exploring viral diversity and composition.
  • To facilitate comparative analyses across multiple viromes.

Main Methods:

  • Development of a web server integrating classical metagenome analysis with specialized viral tools.
  • Implementation of automated phylogenetic analysis for viral marker genes.
  • Inclusion of gene richness estimation using rarefaction curves.
  • Development of sequence similarity-based cross-virome comparison functionalities.

Main Results:

  • Metavir enables exploration of viral diversity via automated phylogenies.
  • Gene richness can be estimated using rarefaction curves within Metavir.
  • Cross-comparison of viromes is facilitated through sequence similarity analysis.
  • The platform provides a comprehensive suite of tools for virome analysis.

Conclusions:

  • Metavir is a unique web server offering comprehensive viral metagenome analysis.
  • The integrated tools enhance the exploration of viral diversity and gene content.
  • Metavir supports comparative viromic studies, advancing the field of virology.