Related Experiment Video

Updated: May 29, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Association of late-preterm birth with asthma in young children: practice-based study

Neera K Goyal1, Alexander G Fiks, Scott A Lorch

  • 1MSCE, Children's Hospital of Philadelphia, 3535 Market St, Suite 1029, Philadelphia, PA 19104. lorch@email.chop.edu.

Pediatrics
|September 14, 2011
PubMed

Insights

Late-preterm birth is linked to increased asthma severity in young children. This includes higher rates of persistent asthma, medication use, and respiratory visits, highlighting a significant risk factor for early childhood health.

Area of Science:

  • Pediatrics
  • Neonatal Medicine
  • Respiratory Medicine

Background:

  • Asthma is a common chronic respiratory disease in childhood.
  • Preterm birth is a known risk factor for adverse health outcomes.
  • The impact of late-preterm birth on childhood asthma requires further investigation.

Purpose of the Study:

  • To evaluate the association between late-preterm birth and asthma severity in young children.
  • To assess the relationship between gestational age and asthma development and health service utilization.

Main Methods:

  • Retrospective cohort study using electronic health records (31 practices).
  • Included 7925 infants born between 34 to 42 weeks gestation (2007-2008), monitored to 18 months.
  • Multivariate logistic/Poisson models analyzed late-preterm (34-36 weeks) and low-normal (37-38 weeks) vs. term (39-42 weeks) gestation.

Main Results:

  • 8.3% of infants diagnosed with asthma by 18 months.
  • Late-preterm birth associated with increased persistent asthma diagnoses (aOR: 1.68), inhaled corticosteroid use (aOR: 1.66), and acute respiratory visits (IRR: 1.44).
  • Low-normal gestation linked to higher asthma diagnoses (aOR: 1.34) and inhaled corticosteroid use (aOR: 1.39).

Conclusions:

  • Late-preterm and low-normal gestational ages are potential risk factors for childhood asthma.
  • These gestational ages may also increase health service utilization in early childhood.
  • Findings suggest closer monitoring for asthma in infants born at these gestations.
Abstract

More Related Videos

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure05:50

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes: