Epigenetic reprogramming: is deamination key to active DNA demethylation?

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Updated: May 29, 2026

Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry
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Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry

Published on: August 16, 2016

Marta Teperek-Tkacz1, Vincent Pasque, George Gentsch

  • 1Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, CB2 1QN, UK. mt446@cam.ac.uk

Reproduction (Cambridge, England)
|September 14, 2011
PubMed

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Epigenetic Regulation

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X-chromosome...
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
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