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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 29, 2026

Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model
05:22

Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model

Published on: October 9, 2015

Circulating tumor cells and PET.

Jian Q Yu1, Massimo Cristofanilli

  • 1Department of Radiology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 14, 2011
PubMed
Summary
This summary is machine-generated.

Targeted cancer therapies require advanced monitoring. Positron emission tomography (PET) and circulating tumor cell analysis offer sensitive methods to track treatment effectiveness in solid tumors.

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Area of Science:

  • Oncology
  • Molecular Imaging
  • Cancer Diagnostics

Background:

  • Solid tumor therapies require precise monitoring beyond size changes.
  • Positron emission tomography (PET) offers sensitive metabolic profiling of tumors.
  • Circulating tumor cells (CTCs) provide a novel avenue for therapeutic evaluation.

Purpose of the Study:

  • To highlight the role of advanced imaging and liquid biopsy in cancer therapy monitoring.
  • To emphasize the utility of PET and CTC analysis for assessing treatment response.
  • To explore the potential of molecular characterization of CTCs in oncology.

Main Methods:

  • Review of current literature on PET imaging in cancer therapy.
  • Analysis of studies involving the detection and molecular characterization of circulating tumor cells.
  • Integration of imaging and liquid biopsy techniques for therapeutic evaluation.

Main Results:

  • PET is a highly sensitive tool for assessing tumor metabolic activity and treatment effects.
  • Detection of CTCs in peripheral blood offers a non-invasive method for monitoring advanced cancers.
  • Molecular analysis of CTCs can provide real-time insights into tumor evolution and treatment resistance.

Conclusions:

  • PET and CTC analysis represent powerful, complementary tools for sensitive cancer therapy monitoring.
  • Molecular characterization of CTCs holds significant promise for personalized cancer care.
  • These advanced techniques enable earlier detection of treatment benefit and facilitate adaptive therapeutic strategies.