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Statins and intracerebral hemorrhage: a retrospective cohort study

Daniel G Hackam1, Peter C Austin, Anjie Huang

  • 1Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Research Bldg, Room 100K, 1400 Western Rd, London, ON N6G 2V2, Canada. dhackam@uwo.ca

Archives of Neurology
|September 14, 2011
PubMed

Insights

Statins, used after ischemic stroke, were not linked to an increased risk of intracerebral hemorrhage (ICH). This population-based study found no association between statin use and ICH in older adults.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Previous research suggested statins might increase intracerebral hemorrhage (ICH) risk.
  • This concern arose from a post hoc analysis in patients with cerebrovascular disease.

Purpose of the Study:

  • To investigate the association between statin therapy and ICH risk.
  • Focus on patients with recent ischemic stroke in a population-based setting.

Main Methods:

  • Retrospective, propensity-matched cohort study in Ontario, Canada.
  • Included 17,872 patients aged 66+ initiating statins post-ischemic stroke.
  • Followed for a median of 4.2 years, assessing ICH via validated coding.

Main Results:

  • No significant association was found between statin use and ICH (HR=0.87; 95% CI, 0.65-1.17).
  • Subgroup and dose-response analyses confirmed these findings.
  • Specificity tests ruled out healthy user bias and differences in care quality.

Conclusions:

  • Statin exposure following ischemic stroke is not associated with an increased risk of intracerebral hemorrhage.
  • Findings suggest statins are safe regarding ICH in this patient population.
Abstract

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