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Auxological criteria for treating children with idiopathic short stature

Sandro Loche1

  • 1Servizio di Endocrinologia Pediatrica, Ospedale Microcitemico - ASL Cagliari, Cagliari, Italy.

Hormone Research in Paediatrics
|September 14, 2011
PubMed

Insights

Biosynthetic growth hormone (GH) treatment can increase adult height in children with idiopathic short stature (ISS). However, predicting individual responses to GH therapy remains challenging, necessitating careful patient selection.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Growth Disorders

Background:

  • Children with idiopathic short stature (ISS) often fail to reach their genetic target adult height.
  • Biosynthetic growth hormone (GH) was approved in 2003 for specific ISS cases unlikely to achieve normal adult height.
  • While GH therapy increases adult height, predicting individual patient response is complex.

Purpose of the Study:

  • To review the efficacy and predictability of growth hormone (GH) treatment in children with idiopathic short stature (ISS).
  • To identify key factors influencing treatment outcomes for ISS patients.

Main Methods:

  • Analysis of auxological variables including age, height at treatment initiation, bone age delay, predicted height, and height velocity.
  • Multivariate analyses were employed to predict treatment outcomes.
  • Evaluation of first-year responsiveness to GH therapy.

Main Results:

  • Controlled studies demonstrate a significant increase in adult height with GH treatment for ISS.
  • Individual responses to GH therapy exhibit considerable variability.
  • Predicting the precise response to GH treatment remains a challenge.

Conclusions:

  • Growth hormone (GH) therapy offers a substantial benefit for increasing adult height in children with idiopathic short stature (ISS).
  • Auxological variables and growth pattern analysis are crucial for guiding treatment decisions.
  • Careful patient selection based on predicted height and growth patterns is essential for optimizing GH therapy outcomes.

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