Cytokine gene expression by human gliomas
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T Lichtor1, G J Dohrmann, M E Gurney
1Section of Neurological Surgery, University of Chicago, Illinois.
Neurosurgery
|May 1, 1990
Abstract:
Two glioma tumor lines and specimens from five patients with gliomas were analyzed to determine genic expression of four growth factors found in human brain. Messenger RNA encoding for interleukin-1 beta, interleukin-6, and basic fibroblast growth factor was found to be expressed in significant amounts in some of these tumors, while mRNA for interleukin-3 was found in small quantities in only the tumor lines. Multiple species of mRNA for basic fibroblast growth factor were found. Expression of growth factor genes may play a role in the growth of human gliomas.