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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Updated: May 29, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

The endocannabinoid system in prostate cancer.

Inés Díaz-Laviada1

  • 1Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcalá, Alcalá de Henares, 28871 Madrid, Spain. ines.diazlaviada@uah.es

Nature Reviews. Urology
|September 14, 2011
PubMed
Summary

The endocannabinoid system is altered in prostate cancer, with cannabinoids showing potential as a novel therapeutic strategy. Further research is needed to explore their full antitumoral effects.

Area of Science:

  • Endocrinology
  • Oncology
  • Pharmacology

Background:

  • The endocannabinoid system, comprising cannabinoids, receptors, and enzymes, regulates numerous physiological functions.
  • Normal prostate tissue contains key endocannabinoid system components like CB1 receptors and fatty acid amide hydrolase in glandular epithelia.

Purpose of the Study:

  • To investigate the role and therapeutic potential of the endocannabinoid system in prostate cancer.
  • To explore the dysregulation of the endocannabinoid system in prostate cancer progression.

Main Methods:

  • Localization of endocannabinoid system components in normal and cancerous prostate tissues.
  • Analysis of correlations between endocannabinoid system component expression and prostate cancer grade/progression.
  • Evaluation of cannabinoid antitumoral properties in prostate cancer models.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Main Results:

  • The endocannabinoid system is dysregulated in prostate cancer, indicating a role in disease homeostasis.
  • Overexpression of endocannabinoid system components correlates with increased prostate cancer grade and progression.
  • Cannabinoids demonstrate antitumoral effects, reducing tumor growth, cell proliferation, and migration in prostate cancer models.

Conclusions:

  • The endocannabinoid system represents a potential therapeutic target for prostate cancer.
  • Cannabinoids exhibit promising antitumoral properties against prostate cancer.
  • Further animal model studies are required to assess the systemic influence on cannabinoid antitumoral actions.