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Innate and adaptive immunity in inflammatory bowel disease
Britta Siegmund1, Martin Zeitz
1Medical Department I (Gastroenterology/Rheumatology/Infectious Diseases), Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany. britta.siegmund@charite.de
World Journal of Gastroenterology
|September 14, 2011
Summary
Inflammatory bowel diseases stem from immune system dysregulation. This review highlights the crucial cross-regulation between innate and adaptive immunity, offering insights into disease mechanisms and potential therapeutic targets.
Area of Science:
- Immunology
- Gastroenterology
Background:
- Inflammatory bowel diseases (IBD) arise from a dysregulated mucosal immune system.
- Innate and adaptive immunity, traditionally studied separately, are increasingly recognized for their interaction in IBD.
Purpose of the Study:
- To review the cross-regulation between innate and adaptive immunity in the context of IBD.
- To illustrate the direct impact of innate and adaptive immune components on each other.
Main Methods:
- Review of functional studies from in vivo models of intestinal inflammation.
- Analysis of results from genome-wide association studies (GWAS).
Main Results:
- Evidence strongly suggests cross-regulation between innate and adaptive immunity in intestinal inflammation.
- Specific examples demonstrate the direct interaction and impact between these two immune arms.
Conclusions:
- Understanding the cross-regulated areas of the mucosal immune system is key to comprehending IBD.
- Identifying these interactions can reveal novel therapeutic targets for inflammatory bowel diseases.
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