Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Crossing Over

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...

Gene Conversion

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

Gene Conversion

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

Pedigree Analysis

Pedigree Analysis

Pedigree Analysis

Pedigree Analysis

Conservative Site-specific Recombination and Phase Variation

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional Pulmonary Atresia With Overlapping Dilated, Hypertrophic, and Excessive Trabeculation Cardiomyopathy in a Neonate With a TPM1 Mutation.

CJC pediatric and congenital heart disease·2026

Same author

Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.

Gut·2026

Same author

Circulating Cell-Free DNA Methylation Profiling Enables Detection, Distinction, and Estrogen Receptor Status Classification of Advanced Breast Cancer.

Cancer research·2026

Same author

Human haematopoietic stem cells remember inflammatory stress.

Nature·2026

Same author

Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions.

Nature communications·2026

Same author

<i>Trans</i>-eQTLs reveal the architecture of human gene regulatory networks.

medRxiv : the preprint server for health sciences·2026

Search research articles

Related Experiment Video

Updated: May 29, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

Age-dependent recombination rates in human pedigrees.

Julie Hussin¹, Marie-Hélène Roy-Gagnon, Roxanne Gendron

¹Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, Canada.

|September 14, 2011

Summary

Maternal age is linked to changes in human recombination. This study found that recombination rates significantly decrease with advancing maternal age, potentially increasing aneuploidy risk.

More Related Videos

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Published on: September 23, 2011

Measuring Microbial Mutation Rates with the Fluctuation Assay

Measuring Microbial Mutation Rates with the Fluctuation Assay

Published on: November 28, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Published on: September 23, 2011

Measuring Microbial Mutation Rates with the Fluctuation Assay

Measuring Microbial Mutation Rates with the Fluctuation Assay

Published on: November 28, 2019

Area of Science:

Human Genetics
Reproductive Biology
Genomic Instability

Background:

Chromosome-number abnormalities, such as trisomies, are associated with altered recombination and increased maternal age.
Understanding age-related effects on recombination is crucial for elucidating mechanisms behind human trisomies.

Purpose of the Study:

To investigate the relationship between maternal age and recombination rate in the human population.
To explore how age-related changes in recombination might contribute to aneuploidy.

Main Methods:

High-resolution localization of crossovers using over 600,000 genetic markers.
Genotyping of 69 French-Canadian pedigrees, analyzing recombination events in 195 maternal meioses.

Main Results:

Observed general patterns of fine-scale recombination rate variation consistent with previous studies.
First observation of a significant decrease in human recombination rates with advancing maternal age.
This decrease is likely chromosome-specific, affecting middle chromosomal arm sections and subtelomeric regions.

Conclusions:

Recombination rates decline with increasing maternal age, potentially impacting chromosome segregation.
Reduced recombination efficiency with maternal age may decrease protection against non-disjunction.
This finding offers a model to explain the association between maternal age and trisomy rates.