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Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
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Irritable Bowel Syndrome

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Related Experiment Video

Updated: May 29, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Intestinal epithelial barrier dysfunction in food hypersensitivity.

Linda Chia-Hui Yu1

  • 1Graduate Institute of Physiology, National Taiwan University College of Medicine, Suite 1020, no. 1 Jen-Ai Road Section I, Taipei 100, Taiwan.

Journal of Allergy
|September 14, 2011
PubMed
Summary
This summary is machine-generated.

Food allergens can cross the intestinal barrier via enhanced transcytosis, bypassing degradation. This process involves IgE and CD23, offering targets for new allergy immunotherapies.

Related Experiment Videos

Last Updated: May 29, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Area of Science:

  • Immunology
  • Gastroenterology
  • Allergy Research

Background:

  • The intestinal epithelial barrier maintains gut homeostasis by preventing pathogen and allergen entry.
  • Normally, undigested proteins are degraded intracellularly or excluded by tight junctions.

Purpose of the Study:

  • To review epithelial barrier dysfunction in sensitized intestines.
  • To elucidate the molecular mechanisms behind enhanced allergen transcytosis.

Main Methods:

  • Review of recent studies on food allergen transport across the intestinal epithelium.
  • Focus on molecular interactions involving IgE, FcεRI, and CD23/FcεRII.

Main Results:

  • Food allergens are transported across the epithelium in large quantities before mast cell activation.
  • Allergens are protected from lysosomal degradation by binding to IgE and CD23/FcεRII.
  • This enhanced transcytosis contributes to allergic responses.

Conclusions:

  • Epithelial barrier dysfunction facilitates allergen passage in sensitized individuals.
  • Targeting IgE and CD23/FcεRII presents a promising avenue for atopic disorder immunotherapies.