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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Related Experiment Video

Updated: May 29, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

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Published on: June 24, 2020

Maternal microchimerism in pediatric inflammatory bowel disease.

David L Suskind1, Denice Kong, Anne Stevens

  • 1Department of Pediatrics; Seattle Children's Hospital; University of Washington; Seattle, WA USA.

Chimerism
|September 14, 2011
PubMed
Summary

Maternal microchimerism, the presence of maternal cells in offspring, was investigated as a cause for inflammatory bowel disease (IBD). Study findings indicate maternal microchimerism is common in IBD patients and controls, with no evidence linking it to IBD development.

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Published on: August 10, 2018

Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Inflammatory bowel disease (IBD) shares immunological similarities with graft-versus-host disease.
  • Maternal cells can transfer to the fetus during pregnancy, potentially influencing fetal immune development.

Purpose of the Study:

  • To investigate the hypothesis that maternal microchimerism contributes to the development of IBD.
  • To determine if maternal cell engraftment in fetuses leads to immune-related conditions like IBD.

Main Methods:

  • Maternal microchimerism was assessed in blood and tissue samples from IBD patients (Crohn's disease, Ulcerative colitis) and controls.
  • Kinetic Polymerase Chain Reaction (kPCR) was used to detect HLA types, identifying maternal and patient-specific cells.
  • Fluorescent in situ hybridization (FISH) was employed to visualize maternal cells in intestinal biopsies.

Main Results:

  • Maternal microchimerism was detected in 56% of IBD patients and 40% of controls (P=NS).
  • Specific analysis for Crohn's disease (50%) and Ulcerative colitis (67%) showed no significant difference compared to controls.
  • FISH analysis did not identify maternal cells in intestinal biopsies of male IBD patients.

Conclusions:

  • The frequency of maternal microchimerism in blood and gut tissues does not differ between IBD patients and disease controls.
  • These findings suggest maternal microchimerism is a common occurrence with no discernible positive or negative impact on IBD.