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Updated: May 29, 2026
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
[Antibacterial activity of nanostructured silver gel]
Aim:
Evaluation of antimicrobial activity of L-cysteine silver gel against various species of pathogenic and opportunistic microorganisms.
Materials And Methods:
Antibacterial activity of L-cysteine silvergel with silver concentration from 1.28 x 10(-3) to 3.75 x10(-3) mole/l was studied by using agar diffusion test. Reparation processes were determined experimentally in 102 male Wistar rats (150 g) by forming under ether anesthesia a 225 mm2 skin wound on the back surface of the body and by introducing virulent strain Staphylococcus aureus 236 24-hour suspension (10(6) CFU/ml) inside the wound. The rat wounds were treated with L-cysteine silver gel once per day for one week and proliferation processes were studied on day 7, 14 and 21.
Results:
Antibacterial activity of L-cysteine silver gel was detected against test strains: S. aureus ATCC 25923; Bacillus subtilis 537; Escherichia coli ATCC 25922; Shigella sonnei 1908; Pseudomonas aeruginosa ATCC 27853; Salmonella typhimurium 5715 and Candida albicans ATCC 885-653. Mean period of wound healing was reduced by 3 days when L-cysteine silver gel was used, index of healing acceleration was approximately 20%.
Conclusion:
L-cysteine silver gel has antibacterial and wound healing properties, it can be used for the creation of new medical preparations.
