Related Experiment Video
Updated: May 29, 2026

Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
Published on: June 2, 2023
[Pathogenesis of lipid storage diseases]
Joanna Bandorowicz-Pikuła1, Slawomir Pikuła, Anna Tylki-Szymańska
1Instytut Biologii Doświadczalnej PAN im. Marcelego Nenckiego w Warszawie. j.bandorowicz-pikula@nencki.gov.pl
Abstract:
Lipidoses are rare genetic disorders characterized by defects of the digestive system that impair the way the body uses dietary fat. When the body is unable to properly digest fats, lipids such as cholesterol, sphingolipids or glycolipids may accumulate in body tissues in abnormal amounts. It has been also suggested that molecular mechanisms leading to development of human diseases, including obesity, diabetes type II and atherosclerosis, consist of impaired transport and storage of lipids, as well as disturbed structure and function of lipid membrane microdomains. In this review we discuss probable mechanisms, including role of lipid membrane microdomains, which may participate in pathogenesis of lipid storage diseases such as Niemann-Pick type A/B and type C, as well as Gaucher type I diseases.
Related Concept Videos
Lysosomal Hydrolases
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Atherosclerosis I: Introduction
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Coronary Artery Disease II: Pathophysiology

