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Comparative dissolution profiles of representative quinolones in different media
M O Akinleye1, A A Jolaoso, H A B Coker
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine Campus, Idi-araba, Lagos, Nigeria. makinleye@unilag.edu.ng
Nigerian Quarterly Journal of Hospital Medicine
|September 15, 2011
Summary
0.1M acetic acid is the optimal dissolution medium for quinolone antibiotics like ciprofloxacin and sparfloxacin, ensuring stable release patterns. This finding aids in comparative dissolution testing and monograph development for these important antimicrobials.
Area of Science:
- Pharmaceutical Sciences
- Drug Development
- Analytical Chemistry
Background:
- Quinolones are broad-spectrum synthetic antimicrobials.
- Understanding their dissolution is crucial for efficacy.
Purpose of the Study:
- To evaluate dissolution efficiencies of ciprofloxacin and sparfloxacin.
- To compare dissolution profiles in various media (0.1N HCl, deionized water, 0.1 M acetic acid, pH 7.4 phosphate buffer).
Main Methods:
- In-vitro dissolution testing of ciprofloxacin and sparfloxacin tablets using USP Apparatus II.
- Quantification of drug release over two hours at nine time points.
- Analysis via High-Performance Liquid Chromatography (HPLC) for concurrent elution.
Main Results:
- 0.1M acetic acid demonstrated the most stable release pattern for both quinolones.
- Sparfloxacin showed instability in 0.1N HCl.
- Ciprofloxacin and sparfloxacin exhibited highest maximum release (%Qmax) in 0.1M acetic acid.
Conclusions:
- 0.1M acetic acid is a suitable candidate for a general-purpose dissolution medium for quinolones.
- Findings support monograph modifications, such as the change for ciprofloxacin in the USP.
- The study provides guidance for regulatory authorities in drug monograph formulation.
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