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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Published on: January 26, 2024

Inflammatory markers in preeclamptic patients.

Murat Can1, Eray Sancar, Muge Harma

  • 1Karaelmas University, Faculty of Medicine, Department of Biochemistry, Karaelmas University of Medicine, Zonguldak, Turkey. drcanmurat@yahoo.com

Clinical Chemistry and Laboratory Medicine
|September 15, 2011
PubMed
Summary

Inflammatory markers like high sensitive C-reactive protein (hsCRP) and serum amyloid A (SAA) are elevated in preeclampsia. These markers, along with procalcitonin, correlate with disease severity, confirming inflammation

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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Maternal-Fetal Medicine

Background:

  • Preeclampsia is a pregnancy complication marked by hypertension and proteinuria.
  • It involves endothelial dysfunction and suggests an increased maternal inflammatory response.
  • This study investigates inflammatory markers in preeclamptic versus normotensive pregnancies.

Purpose of the Study:

  • To evaluate and compare levels of specific inflammatory markers in preeclamptic and normotensive pregnant individuals.
  • To assess the correlation between these inflammatory markers and the severity of preeclampsia.

Main Methods:

  • Inclusion of 36 mild preeclampsia, 36 severe preeclampsia, and 33 normotensive pregnant cases.
  • Measurement of high sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), and procalcitonin using immunoassays.
  • Utilizing mean arterial pressure (MAP) as a disease severity indicator.

Main Results:

  • Severe preeclampsia showed significantly higher hsCRP, SAA, and procalcitonin levels compared to mild preeclampsia and normotensive groups.
  • Mild preeclampsia had elevated SAA and hsCRP versus normotensive controls, with no significant procalcitonin difference.
  • Significant correlations were observed between hsCRP, SAA, procalcitonin, and MAP.

Conclusions:

  • The findings confirm a strong association between inflammatory processes and the development of preeclampsia.
  • Elevated inflammatory markers may serve as indicators of preeclampsia severity.