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Updated: May 29, 2026
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients
Peng-Chan Lin1, Shao-Chieh Lin, Chung-Ta Lee
1Department of Surgery, National Cheng-Kung University Hospital, Tainan, Taiwan.
Purpose:
To measure the CD151 expression in colorectal cancer (CRC).
Methods:
CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis.
Results:
High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites.
Conclusions:
CD151 expression is decreased in patients with metastatic CRC.
