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Related Experiment Video

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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

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Published on: January 13, 2012

Endothelial dysfunction in carotid elongation.

Claudio Baracchini1, Filippo Farina, Simone Tonello

  • 1Department of Neurological Sciences, University of Padua, School of Medicine. claudiobaracchini@tin.it

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|September 15, 2011
PubMed
Summary
This summary is machine-generated.

Severe internal carotid artery kinking impairs blood vessel dilation, potentially increasing carotid dissection risk. This finding highlights the importance of assessing vasodilation in patients with significant carotid elongation.

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

  • Vascular Medicine
  • Neurology
  • Cardiology

Background:

  • Internal carotid artery (ICA) elongation, including coiling and kinking, is a potential risk factor for carotid dissection.
  • Vasomotion, the ability of blood vessels to change diameter, is often impaired in spontaneous cervical vessel dissection.

Purpose of the Study:

  • To investigate whether endothelial-dependent vasodilation is compromised in individuals with carotid coiling and kinking.
  • To determine if the degree of carotid elongation correlates with impaired vasodilation.

Main Methods:

  • A case-control study involving 80 subjects with carotid elongation and 80 healthy controls (HC).
  • High-resolution ultrasound was used to measure flow-mediated dilation (FMD) of the brachial artery.
  • Subjects were categorized based on the hemodynamic impact of kinking, differentiating mild/moderate from severe kinking (peak systolic blood flow velocity >150 cm/s).

Main Results:

  • Flow-mediated dilation (FMD) did not significantly differ between subjects with carotid coiling, mild/moderate kinking, and healthy controls.
  • Subjects with severe carotid kinking exhibited significantly lower FMD compared to the other groups.

Conclusions:

  • Severe internal carotid artery kinking is associated with impaired endothelial-dependent vasodilation.
  • Individuals with severe carotid kinking may be at a higher risk for carotid dissection due to compromised vasodilation.