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Fosfomycin: an old--new antibiotic

R Raz1

  • 1Infectious Diseases Unit, Ha'Emek Medical Centre, Afula, Israel. raz_r@clalit.org.il

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|September 15, 2011
PubMed

Insights

Fosfomycin is a broad-spectrum antibiotic effective against many bacteria. Today, fosfomycin-trometamol offers a convenient oral treatment for uncomplicated urinary tract infections in women.

Area of Science:

  • Pharmacology
  • Microbiology
  • Infectious Diseases

Background:

  • Fosfomycin, a broad-spectrum antibiotic, was discovered in Spain in 1969.
  • It exhibits bactericidal activity against Gram-negative and some Gram-positive bacteria.
  • Initially used parenterally for severe infections, its application has evolved.

Purpose of the Study:

  • To review the current use of fosfomycin, particularly fosfomycin-trometamol.
  • To highlight its efficacy in treating urinary tract infections.
  • To emphasize its role in managing uncomplicated UTIs in women.

Main Methods:

  • Literature review of fosfomycin's properties and clinical applications.
  • Analysis of studies on fosfomycin-trometamol for urinary tract infections.
  • Examination of treatment guidelines and recommendations.

Main Results:

  • Fosfomycin demonstrates broad-spectrum bactericidal activity.
  • Fosfomycin-trometamol provides an effective oral formulation.
  • A single oral dose is indicated for uncomplicated urinary tract infections in women.

Conclusions:

  • Fosfomycin-trometamol is a valuable therapeutic option for uncomplicated UTIs.
  • Its oral administration and single-dose regimen enhance patient compliance.
  • Fosfomycin remains a relevant antibiotic in modern clinical practice.

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