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Related Experiment Video

Updated: May 29, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Fosfomycin: an old--new antibiotic.

¹Infectious Diseases Unit, Ha'Emek Medical Centre, Afula, Israel. raz_r@clalit.org.il

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|September 15, 2011

Summary

Fosfomycin is a broad-spectrum antibiotic effective against many bacteria. Today, fosfomycin-trometamol offers a convenient oral treatment for uncomplicated urinary tract infections in women.

Area of Science:

Pharmacology
Microbiology
Infectious Diseases

Background:

Fosfomycin, a broad-spectrum antibiotic, was discovered in Spain in 1969.
It exhibits bactericidal activity against Gram-negative and some Gram-positive bacteria.
Initially used parenterally for severe infections, its application has evolved.

Purpose of the Study:

To review the current use of fosfomycin, particularly fosfomycin-trometamol.
To highlight its efficacy in treating urinary tract infections.
To emphasize its role in managing uncomplicated UTIs in women.

Main Methods:

Literature review of fosfomycin's properties and clinical applications.
Analysis of studies on fosfomycin-trometamol for urinary tract infections.

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Examination of treatment guidelines and recommendations.

Main Results:

Fosfomycin demonstrates broad-spectrum bactericidal activity.
Fosfomycin-trometamol provides an effective oral formulation.
A single oral dose is indicated for uncomplicated urinary tract infections in women.

Conclusions:

Fosfomycin-trometamol is a valuable therapeutic option for uncomplicated UTIs.
Its oral administration and single-dose regimen enhance patient compliance.
Fosfomycin remains a relevant antibiotic in modern clinical practice.