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Updated: May 29, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
[Clinicopathologic features of primary osteosarcoma in elderly patients]
Yi Ding1, Xiao-hui Niu, Yi Ding
1Department of Pathology, Jishuitan Hospital, Beijing 100035, China. bootman@sina.com
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|September 15, 2011
Summary
Primary osteosarcoma in elderly patients is rare and often overlooked. Accurate diagnosis requires careful correlation of clinical, radiologic, and histologic findings to improve patient outcomes.
Area of Science:
- Oncology
- Orthopedic Surgery
- Radiology
Background:
- Primary osteosarcoma is uncommon in individuals over 60 years old.
- Elderly patients may present with atypical symptoms, delaying diagnosis.
Purpose of the Study:
- To investigate the clinical, radiologic, and pathologic characteristics of primary osteosarcoma in elderly patients.
- To highlight diagnostic challenges and differential diagnoses in this demographic.
Main Methods:
- Retrospective analysis of 12 cases of primary osteosarcoma in patients aged over 60.
- Review of clinical data, radiographic imaging, and histopathologic findings.
- Analysis of follow-up data for treatment outcomes and survival.
Main Results:
- Osteosarcoma occurred in long bones, ilium, craniofacial bones, and soft tissues.
- Radiologic findings included mixed osteosclerotic/osteolytic lesions and periosteal reactions.
- Histopathology revealed conventional osteosarcoma, with some variants; immunohistochemistry had limited diagnostic utility.
Conclusions:
- Primary osteosarcoma in the elderly is rare and frequently misdiagnosed.
- Integrated analysis of clinical, radiologic, and histologic data is crucial for accurate diagnosis.
- Early detection and appropriate management are essential for improving prognosis in elderly osteosarcoma patients.
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