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Published on: March 29, 2019
IGD: a resource for intronless genes in the human genome
Amel Louhichi1, Ahmed Fourati, Ahmed Rebaï
1Research Group on Molecular and Cellular Screening Processes, Laboratory of Microorganisms and biomolecules, P.O. Box 1177, 3018 Sfax, Centre of Biotechnology of Sfax, University of Sfax, Tunisia. amel.louhichi@cbs.rnrt.tn
A new Intronless Gene Database (IGD) has been developed, curating 687 human intronless genes. This resource aids in studying the functional features and genomic distribution of these unique genes.
Area of Science:
- Genomics
- Bioinformatics
Background:
- Intronless genes (IGs) exhibit significant variation in eukaryotic genomes.
- Existing databases lack comprehensive resources for studying IGs collectively.
Purpose of the Study:
- To introduce the Intronless Gene Database (IGD), a curated resource for intronless genes.
- To facilitate the study of functional features and genomic distribution of IGs.
Main Methods:
- Data extraction from GenBank release 183 using Perl scripts.
- Manual curation of gene sequences.
- Analysis of intronless genes based on RefSeq annotation and Gene Ontology.
Main Results:
- The current version of IGD contains 687 human intronless genes.
- Includes protein and CDS sequences for each gene.
- Provides functional classification through Gene Ontology.
Conclusions:
- IGD serves as a valuable resource for retrieving and conducting in silico studies of intronless genes.
- The database is accessible online with detailed user support.
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