Related Experiment Video
Updated: May 29, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Birth characteristics and childhood carcinomas
K J Johnson1, S E Carozza, E J Chow
1The Brown School and Department of Pediatrics, Washington University in St Louis, St Louis, MO 63130, USA. kijohnson@brownschool.wustl.edu
British Journal of Cancer
|September 15, 2011
Summary
Childhood cancer risk may be linked to parental age and gestational factors. This study explored birth characteristics and their association with childhood carcinomas, finding potential links to parental age and lower gestational age.
Area of Science:
- Pediatric Oncology
- Epidemiology
- Reproductive Health
Background:
- Childhood carcinomas are rare and understudied.
- Understanding risk factors for pediatric cancers is crucial.
Purpose of the Study:
- To investigate associations between birth characteristics and childhood carcinomas.
- To identify potential etiological factors for pediatric cancers.
Main Methods:
- Population-based case-control study utilizing linked birth and cancer registries.
- Pooled data from five US states (1980-2004) including 475 carcinoma cases and 57,966 controls.
- Unconditional logistic regression analysis to determine odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- Older maternal age was associated with increased melanoma risk (OR=1.20 per 5-year increase).
- Paternal age was linked to increased risk for any carcinoma (OR=1.10) and thyroid carcinoma (OR=1.16).
- Lower gestational age (<37 weeks) increased thyroid carcinoma risk (OR=1.87). White race was associated with melanoma (OR=3.22).
Conclusions:
- Exploratory findings suggest older parental age and lower gestational age may influence childhood carcinoma etiology.
- Further research is needed to confirm these associations and understand underlying mechanisms.
Related Concept Videos
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
02:12What is Cancer?
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...