Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cortical dynamics of icon perception: effects of concreteness and attractiveness.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same author

Stabilizing and cleaning functional connectivity measures via native eigenspace denoising of resting state fMRI data.

NeuroImage·2026

Same author

Associations between self-reported interoception and resting-state EEG markers in panic disorder: heartbeat-evoked potentials and spectral power.

BMC psychology·2026

Same author

The impact of downsampling on data quality, univariate measurement and multivariate pattern analysis in event-related potential research.

NeuroImage·2026

Same author

Impact of cardiac cycle and respiratory rhythm phase on visual attention in healthy young and older adults.

Scientific reports·2026

Same author

Elucidating Biological Links in Autism Spectrum Disorder: From Blood-Based Risk Factor Identification to a Validated Nomogram for Early Risk Stratification.

Neuropsychiatric disease and treatment·2026

Same journal

Invaders taking over-Mollusc faunal change in volcanic barrier lakes of the Albertine Rift biodiversity hotspot.

PloS one·2026

Same journal

AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways.

PloS one·2026

Same journal

Performance patterns and records in the world aquatics masters championships: Where do the most frequently represented nations among the top-ten masters swimmers come from?

PloS one·2026

Same journal

Modeling diurnal Temperature-Rainfall relationships under multicollinearity using PLS-SEM: A case study of Ghana.

PloS one·2026

Same journal

Organizational culture, social capital, and emergency capacity in primary healthcare institutions: A cross-sectional structural equation modeling study comparing ordinary and older communities.

PloS one·2026

Same journal

Impact of kidney function on the metabolome in the general population.

PloS one·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 29, 2026

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Memory-based mismatch response to frequency changes in rats.

Piia Astikainen¹, Gabor Stefanics, Miriam Nokia

¹Department of Psychology, University of Jyväskylä, Jyväskylä, Finland. piia.astikainen@jyu.fi

|September 15, 2011

Summary

This summary is machine-generated.

Rats exhibit a mismatch response, similar to human mismatch negativity (MMN), to auditory changes. This suggests rats can detect auditory novelty, making them a useful model for studying auditory processing.

More Related Videos

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Related Experiment Videos

Last Updated: May 29, 2026

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Area of Science:

Neuroscience
Auditory Neuroscience
Comparative Cognition

Background:

Auditory changes are crucial for survival, prompting preattentive detection mechanisms.
Human mismatch negativity (MMN) reflects neural comparison of auditory stimuli.
The presence of similar auditory change detection in animals remains largely unexplored.

Purpose of the Study:

To investigate whether rats exhibit a mismatch response analogous to human MMN.
To explore the neural basis of auditory change detection in rats.

Main Methods:

Recording epidural potentials from the primary auditory cortex of urethane-anesthetized rats.
Utilizing an oddball paradigm with standard tones and deviant frequency changes (5% and 12.5% increases).
Manipulating inter-stimulus intervals and comparing oddball to equiprobable conditions.

Main Results:

Mismatch responses were observed in rats 60-100 ms after stimulus onset for increasing, but not decreasing, frequency deviants.
Response magnitude decreased with increased inter-stimulus intervals.
Responses were diminished in equiprobable conditions compared to the oddball paradigm.

Conclusions:

Rat mismatch responses share similarities with human MMN, indicating a conserved neural mechanism for detecting auditory novelty.
Anesthetized rats serve as a valuable model for investigating central auditory processing and neural comparison mechanisms.