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Published on: October 2, 2014
Quantification of brain edema and hemorrhage by MRI after experimental traumatic brain injury in rabbits predicts
Yue-Hua Li1, Jian-Bo Wang, Ming-Hua Li
1Department of Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai 200233, China.
Abstract:
We use multiple MRI modalities to measure cerebral edema and intracerebral hemorrhage quantitatively after TBI in rabbits and to acquire the early prognostic MRI information. Multiple MRI modalities (DCE-MRI, DWI and SWI) were used to assess cerebral edema and intracerebral hemorrhage quantitatively at different time points within a month after TBI in 15 rabbits. The functional outcomes were evaluated at 1 and 30 days after TBI. The relationships between the quantitative MRI information at different time points and functional outcome at 30 days were analyzed. The volume transfer coefficient (K (trans)) in the focal lesion area and the perifocal lesion area at the acute phase correlated with the functional outcome at 30 days (p < 0.05). The apparent diffusion coefficient (ADC) value at 7 days in the focal lesion area correlated with the functional outcome at 30 days (p < 0.01) and had a trend to correlate at 3 days (p = 0.08). In the perifocal lesion area, the ADC values at both acute and subacute phase correlated with the functional outcome at 30 days (p < 0.05). The volume of hemorrhage correlated with functional outcome at 30 days (p < 0.05). The cerebral edema assessed by DCE-MRI (K (trans)) and DWI (ADC) and intracerebral hemorrhage assessed by SWI may have predictive values.
Insights
Quantitative MRI (magnetic resonance imaging) using DCE-MRI, DWI, and SWI can predict functional outcomes after traumatic brain injury (TBI). These imaging techniques assess cerebral edema and hemorrhage, offering early prognostic insights.
Area of Science:
- Neuroimaging
- Traumatic Brain Injury Research
- Biomedical Engineering
Background:
- Traumatic brain injury (TBI) is a leading cause of death and disability.
- Accurate early assessment of TBI severity and prognosis is crucial for effective treatment.
- Current prognostic tools for TBI may lack the sensitivity to capture early pathological changes.
Purpose of the Study:
- To quantitatively assess cerebral edema and intracerebral hemorrhage using multiple MRI modalities after TBI in rabbits.
- To investigate the prognostic value of early MRI findings for functional outcomes at 30 days post-TBI.
- To establish relationships between quantitative MRI parameters and long-term functional recovery.
Main Methods:
- Utilized DCE-MRI, DWI, and SWI in 15 rabbits following TBI.
- Quantitatively measured cerebral edema and intracerebral hemorrhage at various time points.
- Evaluated functional outcomes at 1 and 30 days post-TBI.
- Analyzed correlations between MRI metrics and functional outcomes.
Main Results:
- The volume transfer coefficient (Ktrans) from DCE-MRI in lesion and perifocal areas correlated with 30-day functional outcome (p < 0.05).
- Apparent diffusion coefficient (ADC) values from DWI in the focal lesion area at 7 days correlated with functional outcome (p < 0.01).
- ADC values in the perifocal area and hemorrhage volume also showed significant correlations with functional outcome (p < 0.05).
Conclusions:
- Quantitative MRI metrics, including Ktrans and ADC values, demonstrate predictive value for functional outcomes after TBI.
- SWI-assessed intracerebral hemorrhage volume is also a significant predictor of long-term functional recovery.
- DCE-MRI and DWI-derived parameters offer early prognostic information for TBI patients.
