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Related Experiment Video

Updated: May 29, 2026

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Metformin after bariatric surgery--an acid problem.

J Aberle¹, F Reining, V Dannheim

¹Universitätsklinikum Hamburg-Eppendorf, Sektion Endokrinologie und Diabetologie, Interdisziplinäres Adipositaszentrum, Hamburg. aberle@uke.de

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association

|September 15, 2011

Summary

Metformin use after bariatric surgery requires careful consideration. Elevated ketone bodies post-surgery may increase the risk of lactic acidosis, necessitating a re-evaluation of this common diabetes medication.

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Area of Science:

Endocrinology
Metabolic Surgery
Pharmacology

Background:

Metformin is a first-line oral medication for type 2 diabetes.
Many patients with type 2 diabetes undergo bariatric surgery and continue Metformin treatment.
Metformin use is linked to a risk of lactic acidosis.

Purpose of the Study:

To investigate ketone body levels in patients after bariatric surgery.
To assess the potential implications of Metformin use in the context of post-bariatric surgery metabolic changes.

Main Methods:

Ketone bodies were measured in 90 patients.
Measurements were taken between 5 days and 18 months post-bariatric surgery.

Main Results:

Ketone bodies were significantly elevated in patients during the initial 3-4 months following bariatric surgery.
This elevation indicates a phase of negative energy balance and ketone body formation.

Conclusions:

Metformin use should be critically re-evaluated in patients after bariatric surgery.
The heightened ketone levels in the early post-operative period may increase the risk associated with Metformin therapy.