Mortality from Parkinson's disease: a population-based prospective study (NEDICES).
Ignacio J Posada1, Julián Benito-León, Elan D Louis
1Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain.
Movement Disorders : Official Journal of the Movement Disorder Society
|September 15, 2011
Summary
Parkinson's disease increases mortality risk in the elderly, even after accounting for other health conditions. Those with Parkinson's and dementia face particularly high mortality risks.
Area of Science:
- Epidemiology
- Geriatrics
- Neurology
Background:
- Most Parkinson's disease mortality studies rely on clinical data, limiting generalizability.
- Population-based studies are crucial for understanding disease impact on the wider community.
Purpose of the Study:
- To assess Parkinson's disease (PD) as an independent predictor of mortality in an elderly population.
- To investigate mortality risks associated with PD in a prospective, population-based cohort.
Main Methods:
- Prospective population-based study (Neurological Disorders in Central Spain - NEDICES).
- Cohort of 5262 elderly subjects, with 81 diagnosed with PD at baseline (1994-1995).
- 13-year mortality assessment using Cox regression models, adjusting for demographics and comorbidities.
Main Results:
- Parkinson's disease significantly increased mortality risk (unadjusted HR: 2.29, adjusted HR: 1.75).
- Mortality risk remained elevated in PD patients after adjusting for covariates (P < .001).
- PD patients with dementia exhibited substantially higher mortality risks (adjusted HR: 2.62, P < .001).
Conclusions:
- Parkinson's disease is an independent predictor of mortality in the elderly population.
- Dementia in Parkinson's disease patients is associated with a particularly high risk of mortality.
- Findings highlight the need for comprehensive care addressing both PD and cognitive decline in the elderly.
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