Related Experiment Video
Updated: May 29, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
[Effect of vault irritation on the bulbar respiratory neurons during hypoxia]
Abstract:
Influence of the vault on the impulse activity of respiration center neurons in medulla oblongata and respiration was studied in the norm and during hypoxia. Hypoxia stages served as a test model for ensuing vault effect summation. In normoxia, electrical irritation of the vault had largely an activating effect. Moderate pO2 reduction with rising to the altitudes of 4000-5000 m activated pulsation of the respiratory neurons; influence of vault irritation was less evident than in normoxia even though it prevailed over inhibition. The respiratory neurons activity declined conspicuously at the peak altitude of 7500-8000 m and critical hypoxia; it was then that the facilitatory effect of vault irritation was especially strong. On "descent" to normal atmospheric pressure the spontaneous rhythmic activity of neurons and reaction to irritation returned gradually to baseline values.
More Related Videos
05:45Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
05:28Electrophysiology on Isolated Brainstem-spinal Cord Preparations from Newborn Rodents Allows Neural Respiratory Network Output Recording
Published on: November 19, 2015
Related Concept Videos
Hyperpnea and Hyperventilation
Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Other Factors Affecting Respiration Centers
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical level,...
Chemical Factors Affecting Respiration Centers
CO2 has a potent influence on respiration and is strictly regulated. Under...
Pneumothorax II: Pathophysiology