[Mesangioproliferative glomerulonephritis with IgM deposits as an independent form of nephritis]

On the basis of 32 patients examination clinicomorphological characteristics of the mesangioproliferative glomerulonephritis (MPGN) with IgM deposits are given. The conclusion is drawn that MPGN is a distinct unity in the group of primary GN as well as in the group of IgM--nephropathy. The main pathogenetic component of the development of MPGN with IgM deposits is the fixation of IgM, especially in combination with C3. Moderate hypertrophy and hyperplasia of mesangiocytes, mesamgium enlargement and secondary changes in glomeruli characterize MPGN with IgM deposits electron-microscopically and light optically. MPGN with IgM deposits is followed by nephrotic syndrome in 3/4 cases although other clinical forms of nephritis can also take place. In most cases its clinical course is protracted and benign.