Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
ATP Synthase: Structure01:18

ATP Synthase: Structure

ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
What is Glycolysis?00:56

What is Glycolysis?

Overview
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
Glycolysis: Pay-off Phase01:25

Glycolysis: Pay-off Phase

So far, glycolysis has cost the cell two ATP molecules and produced two small, three-carbon sugar molecules. These molecules will proceed through the second half of the pathway, and sufficient energy will be extracted to pay back the two ATP molecules used as an initial investment and produce a profit for the cell of two additional ATP molecules and two even higher-energy NADH molecules.
Step 1 - 5: Glycolysis Preparatory Phase
The first phase of glycolysis has 5 steps where the glucose is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Pharmacological Basis of Drug Interactions.

The Australian and New Zealand journal of surgery·2017
Same author

Recognition of outstanding contributions to Pediatric Anesthesia with particular reference to Australia and New Zealand.

Paediatric anaesthesia·2013
Same author

From kitchen table to operating room.

Paediatric anaesthesia·2013
Same author

Helping trainees to become good pediatric anesthetists.

Paediatric anaesthesia·2013
Same author

The child in hospital--changes in the last 50 years.

Paediatric anaesthesia·2013
Same author

From arrow poison to neuromuscular blockers.

Paediatric anaesthesia·2013

Related Experiment Video

Updated: May 29, 2026

Assessment of DNase Activity by Ratiometric Fluorescence Resonance Energy Transfer
04:55

Assessment of DNase Activity by Ratiometric Fluorescence Resonance Energy Transfer

Published on: July 25, 2025

Digby Leigh.

T C K Brown1

  • 1(formerly) Department of Anaesthesia, Royal Children's Hospital, Melbourne, Australia. tckbrown@netspace.net.au

Paediatric Anaesthesia
|September 16, 2011
PubMed
Summary

Digby Leigh was a Canadian pediatric anesthesia pioneer. His early career included training with Ralph Waters and participation in the 1964 Paediatric Anaesthesia Workshop.

Area of Science:

  • Medical History
  • Anesthesiology
  • Pediatrics

Background:

  • Digby Leigh, a notable figure in Canadian pediatric anesthesia, began his medical journey in British Columbia and Montreal.
  • He pursued surgical training before transitioning to anesthesiology under Wesley Bourne's influence.
  • Leigh furthered his expertise by training with pioneer Ralph Waters in Madison, Wisconsin.

Discussion:

  • Leigh's contributions were highlighted at the 1964 First Paediatric Anaesthesia Workshop in Toronto.
  • He participated in a panel alongside distinguished anesthetists Jackson Rees and Bob Cope.
  • The workshop's opening, 'We are all enemies,' set a tone for dynamic professional exchange.

Key Insights:

  • Leigh's career trajectory exemplifies dedication to pediatric anesthesia.

More Related Videos

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

Related Experiment Videos

Last Updated: May 29, 2026

Assessment of DNase Activity by Ratiometric Fluorescence Resonance Energy Transfer
04:55

Assessment of DNase Activity by Ratiometric Fluorescence Resonance Energy Transfer

Published on: July 25, 2025

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

  • His training with Ralph Waters placed him among early leaders in the field.
  • Participation in significant workshops underscores his role in advancing pediatric anesthesia practices.
  • Outlook:

    • Further research into Leigh's specific innovations would be valuable.
    • Documenting the experiences of pioneers like Leigh is crucial for medical history.
    • Understanding the evolution of pediatric anesthesia through figures like Leigh offers insights into modern practices.