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Elevation of plasma soluble CD26 levels during pregnancy
Shuming Zhao1, Min Song, Yahan Fan
1Departments of Blood Transfusion Obstetrics and Gynecology, Southwest Hospital Department of Clinical Biochemistry, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China. chuminhu@163.com
The Journal of Obstetrics and Gynaecology Research
|September 16, 2011
Summary
Soluble CD26 (sCD26) levels are significantly higher in pregnant women compared to non-pregnant women. This suggests CD26 plays a role in successful pregnancy, influencing immune regulation during gestation.
Area of Science:
- Immunology
- Reproductive Biology
- Biochemistry
Background:
- CD26, a transmembrane protein with dipeptidyl peptidase IV (DPPIV) activity, is expressed on various cell types.
- Previous research links CD26 and its enzymatic activity to immune-mediated disorders.
- Immune regulation is crucial for successful pregnancy outcomes.
Purpose of the Study:
- To investigate the potential role of CD26 in pregnancy.
- To determine the association between circulating soluble CD26 (sCD26) levels and pregnancy outcomes.
Main Methods:
- Developed an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) using a hybridoma cell line (1F1).
- Measured maternal plasma sCD26 levels in 80 normal pregnant women and 45 non-pregnant women.
Main Results:
- Plasma sCD26 levels were significantly elevated in the pregnant group compared to the non-pregnant group (P < 0.001).
- This indicates a strong correlation between pregnancy status and circulating sCD26 concentrations.
Conclusions:
- CD26 appears to play a role in successful pregnancy.
- sCD26 is not an absolute marker for Th1-type immunity, supporting the dominant Th2-type immunity observed during pregnancy.
