What is the frequency of carbohydrate metabolism disorder in CKD?

The objective of this paper is to detect the incidence of insulin resistance (IR) in Chronic Kidney disease (CKD) patients and the presence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) in patients with/without IR.

We enrolled 113 patients with CKD. Biochemical parameters were investigated.

IFG was found 59.3% of patients with CKD. Age (p = 0.012), BMI (p = 0.036), TG (p = 0.008), HbA1c(p = 0.002), hs-CRP (p = 0.015) levels were higher in patients with IFG. According to the results of Oral glucose tolerance test (OGTT), 69% of patients with CKD had a detected carbohydrate metabolism disorder, 9.7% had DM, 59.3% had IGT. In patients with IFG 13.6% had DM, 31.8% IGT, in patients without IFG 4.2% had DM and 29.8% IGT. The mean HOMA-IR and insulin levels were 3.03 ± 1, 97/11.9 ± 7.13. IR was detected 23% of patients with CKD. In patients with IR; FBG (p = 0.003), serum insulin (p = 0.001), TG (p = 0.05) and HbA1c (p = 0.004) levels were elevated. 31.3% of patients with IFG were found to be IR.

Carbohydrate metabolism disorder and insulin resistance are found in patients with CKD. Most patients with CKD who are elderly, obesity or overweight offer targets for additional risk factors. For these reasons, screening for DM may be recommended.