Related Experiment Video
Updated: May 29, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Nephrotic and anti-phospholipid syndromes: multisystem conditions associated with acute myocardial infarction in
Muhammad M Javaid1, Antigoni Grigoriou, Dimitrios Katsianos
1Department of Nephrology, King's College Hospital NHS Foundation Trust, London, United Kingdom. mmjavaid@doctors.org.uk
Abstract:
Acute myocardial infarction is relatively uncommon in patients under the age of 40 years. Unlike the older patients where rupture of coronary artery atherosclerotic plaque is the main underlying pathology, the pathogenesis in younger patients can be varied and may require different diagnostic and therapeutic approaches. Hypercoagulable state associated with nephrotic syndrome and antiphospholipid syndrome can lead to the development of occlusive coronary artery thrombus in absence of atherosclerotic coronary artery disease. Acute myocardial infarction in such a setting can sometimes be the first manifestation of an underlying disease. We describe a case of myocardial infarction in a young man with both nephrotic and antiphospho-lipid syndromes and present a brief literature review.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Endocarditis II: Clinical Features of Infective Endocarditis
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis I: Introduction
Acute Coronary Syndrome I: Introduction