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Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart

Lu Q Chen1, Anand Rohatgi, Colby R Ayers

  • 1The Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9047, United States.

Atherosclerosis
|September 16, 2011
PubMed
Abstract

Insights

Higher myeloperoxidase (MPO) levels are linked to aortic atherosclerosis, particularly in African Americans. This finding suggests MPO may contribute to racial disparities in vascular disease risk.

Area of Science:

  • Cardiovascular Research
  • Biomarkers and Disease
  • Vascular Biology

Background:

  • Myeloperoxidase (MPO) is an enzyme implicated in atherosclerosis development.
  • Understanding MPO's role in different vascular beds is crucial.

Purpose of the Study:

  • To investigate the association between circulating MPO levels and coronary and aortic atherosclerosis.
  • To examine these associations in a large, multiethnic population.

Main Methods:

  • Plasma MPO levels were measured in 3294 participants of the Dallas Heart Study.
  • Coronary artery calcification (CAC) assessed by EBCT; abdominal aorta plaque (AP), burden (APB), and wall thickness (AWT) by MRI.
  • Multivariable analyses adjusted for traditional risk factors and inflammatory biomarkers.

Main Results:

  • Elevated MPO associated with prevalent AP, APB, and AWT, but not CAC.
  • MPO remained linked to aortic atherosclerosis markers after adjusting for other inflammatory markers.
  • A significant interaction showed MPO associated with AP in African Americans but not other groups.

Conclusions:

  • Higher MPO levels are associated with aortic, but not coronary, atherosclerosis.
  • The association between MPO and aortic atherosclerosis was significant in African American participants.
  • MPO may represent a novel risk factor contributing to racial disparities in peripheral vascular disease.

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