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Updated: May 29, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Clinical, anatomic, and procedural durability of carotid revascularization
Kevin M Barrett1, Raid G Ossi, Thomas G Brott
1Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA. barrett.kevin@mayo.edu
Insights
Carotid endarterectomy and angioplasty with stenting durability varies. This review compares long-term outcomes of these carotid revascularization methods beyond the initial perioperative period.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Clinical Trials
Background:
- Carotid revascularization using endarterectomy or angioplasty with stenting is common.
- Current research often compares short-term procedural and composite outcomes.
- Long-term durability of these interventions is less understood.
Purpose of the Study:
- To review factors influencing the durability of carotid revascularization.
- To compare the durability of carotid endarterectomy versus angioplasty with stenting.
- To analyze data from randomized clinical trials for long-term outcomes.
Main Methods:
- Systematic review of Phase III randomized clinical trials.
- Analysis of durability defined by clinical, anatomic, and procedural factors.
- Focus on outcomes beyond the perioperative risk period.
Main Results:
- Durability comparison between carotid endarterectomy and angioplasty with stenting is limited in current literature.
- Factors influencing long-term success require further investigation.
- Data from randomized trials suggest varying durability profiles.
Conclusions:
- Long-term durability is a critical, yet understudied, aspect of carotid revascularization.
- Further research is needed to fully compare the durability of carotid endarterectomy and angioplasty with stenting.
- Understanding durability is essential for patient selection and long-term management.
Abstract:
Carotid endarterectomy and carotid angioplasty with stenting are 2 common approaches to revascularization. Phase III randomized clinical trials have focused on comparisons of periprocedural outcomes and composite outcomes that combine procedural events and clinical events during follow-up. The comparison of outcomes beyond the perioperative risk period, where the principal concern is durability, defined in clinical, anatomic, and procedural terms, has received less attention. The purpose of this review is to discuss factors that may influence durability and to compare the durability of carotid revascularization techniques beyond the perioperative period using data from randomized clinical trials.
