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Updated: May 29, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Selecting targeted therapies for patients with renal cell carcinoma

Elizabeth R Plimack1, Gary R Hudes

  • 1Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111-2497, USA. elizabeth.plimack@fccc.edu

Journal of the National Comprehensive Cancer Network : JNCCN
|September 16, 2011
PubMed

Insights

Choosing treatments for advanced renal cell carcinoma (RCC) is complex due to many new options. This guide helps clinicians select therapies based on disease type, patient factors, and clinical data for better outcomes.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Advanced renal cell carcinoma (RCC) presents diverse histology and biology, impacting treatment response.
  • The last five years have seen the approval of six new agents for RCC, with more in development.
  • The expanding therapeutic landscape poses challenges for clinicians in selecting optimal treatment strategies.

Purpose of the Study:

  • To provide practical guidance for clinicians on selecting treatments for advanced renal cell carcinoma (RCC).
  • To integrate clinical trial data with patient-specific factors for personalized treatment recommendations.
  • To supplement existing NCCN Clinical Practice Guidelines for advanced RCC management.

Main Methods:

  • Review of clinical trial data for newly approved and investigational agents in RCC.
  • Analysis of patient characteristics, including histology, comorbidities, and preferences.
  • Synthesis of evidence-based data and clinical considerations for treatment selection.

Main Results:

  • Development of recommendations for first-line and subsequent treatments for clear cell and non-clear cell RCC.
  • Integration of disease setting, histology, and patient factors into treatment decision-making.
  • Guidance on navigating the complex treatment options for advanced RCC.

Conclusions:

  • Treatment selection for advanced RCC requires a multifaceted approach considering disease and patient variables.
  • The provided recommendations aim to aid clinicians in optimizing therapy choices.
  • Personalized treatment strategies are crucial for managing heterogeneous advanced RCC cases.

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