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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: May 29, 2026

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Brain amyloid imaging.

Christopher C Rowe1, Victor L Villemagne

  • 1Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia. christopher.rowe@austin.org.au

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 16, 2011
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) imaging of brain beta-amyloid plaques using (18)F-labeled tracers will soon aid Alzheimer disease (AD) diagnosis. This guide prepares nuclear medicine physicians for interpreting these emerging amyloid imaging scans.

Related Experiment Videos

Last Updated: May 29, 2026

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiology

Background:

  • Alzheimer disease (AD) prevalence is increasing with an aging population.
  • Early diagnosis and treatment are crucial for managing AD.
  • Brain amyloid imaging with positron emission tomography (PET) is emerging as a key diagnostic tool.

Purpose of the Study:

  • To provide nuclear medicine physicians with essential background knowledge for interpreting (18)F-labeled tracer PET scans for amyloid plaque detection.
  • To explain the relationship between amyloid deposition and cognitive decline in AD.
  • To prepare physicians for practical training in amyloid PET scan interpretation.

Main Methods:

  • Review of current literature and clinical guidelines on amyloid PET imaging.
  • Discussion of image acquisition, display, and interpretation principles.
  • Explanation of tracer binding patterns in AD and other dementias.

Main Results:

  • (18)F-labeled tracer PET imaging for brain beta-amyloid plaques is nearing clinical availability.
  • Understanding the link between amyloid burden and cognitive status is vital for accurate diagnosis.
  • Recognizing diverse tracer binding patterns is necessary for differentiating AD from other neurodegenerative conditions.

Conclusions:

  • Amyloid PET imaging will become a standard investigation for assisting AD diagnosis.
  • Nuclear medicine physicians require specialized knowledge to effectively utilize and interpret these scans.
  • This article serves as a foundational resource for physicians preparing for amyloid PET interpretation.