Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of second sample testing in Indian children suffering from tuberculosis with rifampicin indeterminate results on Xpert MTB/Rif and Xpert Ultra assays.

The Indian journal of tuberculosis·2026
Same author

The Dance of Wuchereria bancrofti on Ultrasound.

Indian journal of pediatrics·2026
Same author

Pediatric acute liver failure in a child with arsenic toxicity and underlying rotor syndrome.

Oxford medical case reports·2026
Same author

Intestinal failure-associated liver disease in a child with short bowel syndrome: management issues.

Oxford medical case reports·2026
Same author

Esophageal Stricture in a 5-Year-Old Child with Epidermolysis Bullosa: Case Report of a Rare Complication at a Very Young Age.

Case reports in gastroenterology·2026
Same author

Antibiotic Prophylaxis Optimization Using Fecal Surveillance Culture in Operated Biliary Atresia Patients: A Retrospective Study on Cholangitis Prevention.

Journal of Indian Association of Pediatric Surgeons·2026

Related Experiment Video

Updated: May 29, 2026

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

Evolving biliary atresia with cytomegalovirus.

Sweta Mohanty1, Ira Shah, Sushmita Bhatnagar

  • 1Pediatric Hepatobiliary Clinic, BJ Wadia Hospital for Children, Mumbai, India.

Indian Pediatrics
|September 16, 2011
PubMed
Summary

Cytomegalovirus (CMV) infection may contribute to biliary atresia in infants. This study presents two cases where CMV infection led to intrahepatic cholestasis and subsequent biliary atresia development.

Area of Science:

  • Virology
  • Pediatric Gastroenterology
  • Hepatology

Background:

  • Biliary atresia is a rare but serious liver disease in infants, characterized by bile duct obstruction.
  • The etiology of biliary atresia remains largely unknown, with viral infections being a suspected cause.
  • Cytomegalovirus (CMV) is known to cause liver damage, but its direct role in biliary atresia is not established.

Observation:

  • Two infant cases initially presented with intrahepatic cholestasis, a condition of impaired bile flow within the liver.
  • Both infants were diagnosed with cytomegalovirus (CMV) infection.
  • Following the CMV infection, both infants progressed to develop biliary atresia.

Findings:

  • The presented cases suggest a potential link between cytomegalovirus (CMV) infection and the development of biliary atresia.

Related Experiment Videos

Last Updated: May 29, 2026

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

  • CMV infection may trigger or exacerbate the pathological processes leading to bile duct destruction in susceptible infants.
  • Intrahepatic cholestasis can be an early clinical manifestation of CMV-associated biliary injury.

    • Implications:

    • These findings warrant further investigation into the role of CMV as a causative or contributing factor in biliary atresia.
    • Understanding the viral etiology could lead to novel diagnostic markers and therapeutic strategies for biliary atresia.
    • This research highlights the importance of considering viral infections in the differential diagnosis of neonatal cholestatic liver diseases.