Influenza-associated pediatric deaths--United States, September 2010-August 2011

    Insights

    Influenza caused 115 pediatric deaths from 2010-2011, with many children lacking high-risk conditions. Increasing annual influenza vaccination for children is crucial to prevent severe illness and fatalities.

    Area of Science:

    • Pediatric Infectious Diseases
    • Public Health Surveillance
    • Vaccinology

    Background:

    • Influenza-associated pediatric mortality is a notifiable disease in the US since 2004.
    • Understanding trends and risk factors is vital for public health interventions.

    Purpose of the Study:

    • To summarize influenza-associated pediatric deaths reported to the CDC between September 2010 and August 2011.
    • To analyze demographic and clinical characteristics of these cases.
    • To assess the impact of influenza vaccination on pediatric mortality.

    Main Methods:

    • Retrospective analysis of nationally notifiable influenza-associated pediatric mortality cases reported to the CDC.
    • Data collection included demographics, medical conditions, location of death, and vaccination status.
    • Descriptive statistics were used to summarize findings.

    Main Results:

    • 115 deaths occurred across 33 states during the 2010-2011 influenza season.
    • Nearly half of deaths (46%) were in children younger than 5 years.
    • 49% of deceased children had no known high-risk conditions, and 23% of vaccinated children (aged ≥6 months) were fully vaccinated.

    Conclusions:

    • Influenza poses a significant risk to children, including those without pre-existing high-risk conditions.
    • Current influenza vaccination coverage among pediatric deaths remains suboptimal.
    • Enhanced strategies are needed to improve influenza vaccination rates in children to prevent mortality.

    Related Concept Videos

    Influenza01:27

    Influenza

    Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
    Vaccinations01:51

    Vaccinations

    Overview
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
    Infectious Diseases and Their Occurrence01:28

    Infectious Diseases and Their Occurrence

    Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
    Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

    Pharmacokinetics: Drug–Food and Drug–Viral Interactions

    A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...
    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...