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Updated: May 29, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Severe hyponatraemia during therapy with ramipril
1Royal Worcester Hospital, Charles Hastings Way, Worcester, Worcester, G75 8RG, UK.
Abstract:
An older patient who was being treated with ramipril, chlorpromazine and aspirin presented with hypotension and serum sodium of 119 mmol/litre. The patient was treated with intravenous saline and all drug therapy was stopped. Serum sodium rose following fluid therapy. Ramipril was restarted as the patient's blood pressure increased. Serum sodium dropped to 112 mmol/litre. The patient's thyroid and adrenal functions were within normal limits, as were liver function tests and C-reactive protein. The hyponatraemia corrected when the patient was placed on fluid restriction and treatment with ramipril stopped.
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