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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: May 29, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Rodent models of aging bone: an update.

Farhan A Syed1, Terry Melim

  • 1Abbott Bioresearch Center, Worcester, MA 01545, USA. farhan.syed@abbott.com

Current Osteoporosis Reports
|September 16, 2011
PubMed
Summary

Aging bone loss, or osteoporosis, increases fracture risk in older adults. Research in animal models reveals how hormones, nutrition, and cellular changes contribute to this, informing new treatments for healthier aging.

Area of Science:

  • Gerontology and Skeletal Biology
  • Investigating age-related changes in bone health and the skeletal system.

Background:

  • Increasing life expectancy highlights the need to address age-related bone diseases like osteoporosis.
  • Osteoporosis in the elderly leads to fractures, reduced quality of life, and significant healthcare costs.

Purpose of the Study:

  • To review recent research on factors influencing age-related bone loss in murine and rodent models.
  • To explore the interplay between bone and marrow fat, and the differentiation of mesenchymal stromal cells with age.

Main Methods:

  • Review of studies utilizing aging murine and rodent models.
  • Analysis of research on extrinsic factors (hormones, nutrition, exercise) and intrinsic factors (cytokines, oxidative stress).
  • Examination of studies on bone marrow adipogenesis and osteoblastogenesis.

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Main Results:

  • Identified various extrinsic and intrinsic factors impacting the aging skeleton.
  • Highlighted the shift in marrow mesenchymal stromal cell fate towards adipogenesis with age.
  • Demonstrated the complex cellular and molecular changes underlying age-related bone loss.

Conclusions:

  • Understanding the pathways and cellular players in bone aging is crucial.
  • This knowledge can lead to improved pharmacologic and non-pharmacologic interventions for age-related bone loss.
  • Future research in aging bone models can inform strategies to mitigate osteoporosis and fractures in the geriatric population.