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Updated: May 29, 2026

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
Published on: January 19, 2024
Melasma: a comprehensive update: part II
Vaneeta M Sheth1, Amit G Pandya2
1Department of Dermatology at Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Abstract:
Several methods of treatment are available to patients with melasma. First-line therapy usually consists of topical compounds that affect the pigment production pathway, broad-spectrum photoprotection, and camouflage. Second-line therapy often consists of the addition of chemical peels, although these must be used cautiously in patients with darker skin. Laser and light therapies represent potentially promising options for patients who are refractory to other modalities, but also carry a significant risk of worsening the disease. A thorough understanding of the risks and benefits of various therapeutic options is crucial in selecting the best treatment.
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