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Published on: July 21, 2023
Cardiovascular pharmacogenomics
Dan M Roden1, Julie A Johnson, Stephen E Kimmel
1Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0575, USA. dan.roden@vanderbilt.edu
Circulation Research
|September 17, 2011
Summary
Genetic factors significantly impact how patients respond to medications. This review explores methods for identifying genetic variations that influence drug efficacy and discusses implementation strategies.
Area of Science:
- Pharmacogenomics
- Clinical Pharmacology
- Genetics
Background:
- Patient responses to drug therapy exhibit considerable variability.
- A portion of this inter-individual variability in drug response is attributable to genetic factors.
- Understanding these genetic influences is crucial for optimizing therapeutic outcomes.
Purpose of the Study:
- To review general methodologies for identifying genetic variations that affect drug response.
- To provide examples of genetic influences on drug response across various therapeutic areas.
- To briefly discuss potential pathways for implementing pharmacogenomic approaches in clinical practice.
Main Methods:
- Literature review of approaches to identify genetic determinants of drug response.
- Synthesis of examples from key therapeutic areas including cardiovascular medicine.
- Discussion of implementation strategies for pharmacogenomic data.
Main Results:
- General strategies for identifying genetic variations influencing drug response are outlined.
- Specific examples illustrate genetic impacts on drug response in cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet therapy.
- Potential implementation pathways are considered.
Conclusions:
- Genetic variations play a significant role in patient drug response.
- Systematic approaches can identify these genetic influences.
- Implementation of pharmacogenomics holds promise for personalized medicine.
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