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Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology

Andrew J K Phillips1, Charles A Czeisler, Elizabeth B Klerman

  • 1Division of Sleep Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ajphillips@partners.org

Journal of Biological Rhythms
|September 17, 2011
PubMed
Summary

Human circadian rhythms can desynchronize due to behavioral influences, leading to altered sleep patterns. This study models how orexinergic signals and weakened circadian input cause internal desynchrony and bicircadian rhythms.

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